| Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. | |
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MedLine Citation:
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PMID: 20567168 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To further evaluate the relationship between thyroid antibodies and preterm births. METHODS: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First- and Second-Trimester Risk of Aneuploidy [FaSTER] trial). RESULTS: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. CONCLUSION: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation. LEVEL OF EVIDENCE: II. |
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Authors:
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James E Haddow; Jane Cleary-Goldman; Monica R McClain; Glenn E Palomaki; Louis M Neveux; Geralyn Lambert-Messerlian; Jacob A Canick; Fergal D Malone; T Flint Porter; David A Nyberg; Peter S Bernstein; Mary E D'Alton; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 116 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 58-62 Citation Subset: AIM; IM |
Affiliation:
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Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, USA. jhaddow@ipmms.org |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HD 38652/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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