Document Detail

Thyroparathyroidectomy modifies the skeletal response to aluminum loading in the rat.
MedLine Citation:
PMID:  3586498     Owner:  NLM     Status:  MEDLINE    
Diminished parathyroid hormone (PTH) secretion may contribute to the accumulation of aluminum (Al) in bone and to impaired bone formation in Al-related bone disease. Therefore, intact (AL, N = 9) and thyroparathyroidectomized (TPTX-AL, N = 9) rats were given intraperitoneal injections of Al, 2 mg/day, for 42 days; intact control (C, N = 11) and TPTX control (TPTX-C, N = 9) animals received i.p. injections of vehicle only. Quantitative bone histology and measurements of mineralized bone formation (Rbf) using double tetracycline labeling were done for cortical and for trabecular bone; trabecular bone aluminum content (BA) was determined by histochemical methods. BA did not differ between AL and TPTX-AL, 33 +/- 13% versus 39 +/- 14%, and Rbf decreased similarly from control values in both Al-treated groups. In contrast, osteoid production was impaired to a greater extent in TPTX-AL than in AL. Thus, osteoid area and osteoid seam width were each lower in TPTX-AL than in TPTX-C; these values did not differ between AL and C. TPTX can aggravate Al induced reductions in osteoid synthesis, and low serum PTH levels may contribute to the pathogenesis of aplastic bone. However, reductions in Rbf during Al loading are not mediated by PTH.
W G Goodman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  31     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-22     Completed Date:  1987-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  923-9     Citation Subset:  IM    
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MeSH Terms
Aluminum / metabolism,  toxicity*
Bone and Bones / metabolism
Osteomalacia / etiology*
Parathyroid Glands / physiology*
Parathyroid Hormone / blood
Thyroid Gland / physiology*
Reg. No./Substance:
0/Parathyroid Hormone; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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