| Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. | |
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MedLine Citation:
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PMID: 19917474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the literature, we are reporting 5 additional cases. All the 5 patients were adult females, with ages from 38 to 79 years, who presented with thyroid masses. Four of the patients had normal thyroid function tests and one had mild hypothyroidism. All patients received partial or total thyroidectomy. The thyroid specimens showed either circumscribed yellow-tan masses (cases 1, 2, and 3) or diffuse yellow-brown discoloration (cases 4 and 5). Histologic examination revealed abundant mature fat infiltrating the affected thyroid tissue in 3 distinct patterns: (1) fat infiltration limited to follicular adenomas (thyrolipoma); (2) fat diffusely infiltrating throughout the thyroid gland (thyrolipomatosis); or (3) fat infiltration involving both follicular adenoma and their surrounding thyroid tissue. Because of the rarity of thyroid fat-containing lesions, confusion in differential diagnosis may occasionally occur. It is important to be aware during frozen section that these lesions may present as extrathyroidal nodules, which can be radioactive on intraoperative scan for parathyroid glands. In addition, a papillary thyroid carcinoma was also identified in one case of thyrolipomatosis. All patients recovered well after surgery and there has been no recurrence of the lesions after 1 to 24 years of clinical follow-up. In summary, we are reporting 5 rare cases of thyrolipoma and thyrolipomatosis with distinct histologic patterns. Previously reported cases of thyrolipomatosis were reviewed and analyzed with the current cases. |
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Authors:
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Yimin Ge; Mario A Luna; Daniel F Cowan; Luan D Truong; Alberto G Ayala |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Annals of diagnostic pathology Volume: 13 ISSN: 1532-8198 ISO Abbreviation: Ann Diagn Pathol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800503 Medline TA: Ann Diagn Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 384-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Weill Medical College of Cornell University, The Methodist Hospital, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Combined Modality Therapy Female Humans Lipoma / drug therapy, pathology*, surgery Lipomatosis / drug therapy, pathology*, surgery Middle Aged Thyroid Diseases / drug therapy, pathology*, surgery Thyroid Function Tests Thyroidectomy Thyroxine / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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