Document Detail


Thyroiditis after pregnancy loss.
MedLine Citation:
PMID:  9253317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a case series evaluating the development and characteristics of thyroiditis following pregnancy loss. Five women were followed prospectively with measurement of thyroid function and antithyroid antibodies after pregnancy loss. Serum TSH concentrations were measured by immunoradiometric assay and antithyroid antibodies by RIA and hemagglutination techniques. All women had normal serum TSH concentrations before conception or at the time of pregnancy loss, and all but one had positive antithyroid antibodies. Pregnancy loss occurred between 5-20 weeks gestation because of ectopic pregnancy or either spontaneous or elective abortion. Two women had subclinical hypothyroidism with peak serum TSH values of 8.7 mU/L and 5.4 mU/L at 2 and 7 months after pregnancy loss, respectively. Three women had clinical hyperthyroidism with serum TSH values < or = 0.2 mU/L diagnosed between 3-11 months after pregnancy loss followed subsequently by a hypothyroid phase. Painless thyroiditis within 1 yr of pregnancy loss in these women suggests that the immunological changes of a short-term gestation may be sufficient to lead to thyroiditis.
Authors:
E Marqusee; J A Hill; S J Mandel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  82     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-28     Completed Date:  1997-08-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2455-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / complications*
Adult
Autoantibodies / blood
Female
Humans
Hyperthyroidism / blood,  diagnosis
Hypothyroidism / complications,  drug therapy
Pregnancy
Prospective Studies
Thyroid Gland / immunology
Thyroiditis, Autoimmune / complications*
Thyrotropin / blood
Thyroxine / administration & dosage,  therapeutic use
Time Factors
Grant Support
ID/Acronym/Agency:
DK02221/DK/NIDDK NIH HHS; HD23547/HD/NICHD NIH HHS; HL07609/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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