| Thyroid uptake of 201thallium and its control by TSH. | |
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MedLine Citation:
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PMID: 6267856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients injected with 201Thallium (201Tl) for myocardial scanning present good thyroid visualization. Determinations in mice injected with 201Tl indicated a high thyroid/serum concentration ratio (T/S). The 201Tl biological half-life (t 1/2) in serum (30 - 135 s) was much shorter than in thyroid (53 - 55 h) for human subjects and experimental animals. The 1 h 201Tl T/S ratio was comparable to that of 131I and 99mTc, indicating presence of a gradient for 201Tl also. Increase of endogenous TSH induced by propylthiouracil led to a significant rise in in T/S for 99mTc, 131I and 201Tl, whereas TSH inhibition by feeding l-thyroxine led to decrease in T/S for 99mTc and 201Tl. In vitro thyroid/medium concentration ratio (T/M) of 99mTc and 201Tl was decreased after 20' incubation with ouabain, an inhibitor of the Na+, K+, activated ATP-ase. However, perchlorate in vitro or in vivo failed to diminish the 201Tl T/M ratios or to affect the t 1/2 of 201Tl in human subjects, whereas T/M of 201Tl was depressed by KCl addition to the medium. |
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Authors:
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M L Maayan; E M Volpert; E J Fine; J Eisenberg; E M Lopez; F P Dawry |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Acta endocrinologica Volume: 97 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-10-14 Completed Date: 1981-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 461-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Half-Life Humans Male Mice Ouabain / pharmacology Perchloric Acid / pharmacology Propylthiouracil / pharmacology Protein Binding / drug effects Radioisotopes / diagnostic use* Sodium Iodide / pharmacology Thallium / metabolism* Thyroid Gland / metabolism* Thyrotropin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 51-52-5/Propylthiouracil; 630-60-4/Ouabain; 7440-28-0/Thallium; 7601-90-3/Perchloric Acid; 7681-82-5/Sodium Iodide; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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