| Thyroid-stimulating immunoglobulins do not cause non-autonomous, autonomous, or toxic multinodular goitres. | |
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MedLine Citation:
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PMID: 87964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyroid-stimulating immunoglobulins (TSIs) were measured by radioreceptor assay in serum from 51 patients with a multinodular goitre, divided into four groups according to thyroid function, and in 30 normal people. In 9 patients who were euthyroid and had non-autonomous thyroid function and in 6 patients who were hyperthyroid, TSI index was normal . Of 21 euthyroid patients with autonomous function only 2 had a slightly abnormal TSI index (66 in both, normal greater than or equal to 68). Another series of 15 clinically euthyroid patients also had a normal TSI index. These results suggest that TSIs do not contribute to the pathogenesis of multinodular goitre, as has been suggested by others. |
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Authors:
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J H Bolk; J W Elte; J K Bussemaker; A Haak; D van der Heide |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 61-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Goiter, Nodular / etiology*, physiopathology Humans Immunoglobulins / analysis* Long-Acting Thyroid Stimulator / physiology* Male Middle Aged Radioligand Assay / methods Thyroid Function Tests Thyroid Gland / immunology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 9034-48-4/Long-Acting Thyroid Stimulator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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