Document Detail

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases.
MedLine Citation:
PMID:  11018848     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN: Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING: A public university referral center [CAISM/Hospital das Clínicas, Faculty of Medicine, University of Campinas, Campinas, SP]. PARTICIPANTS: 415 neonates divided into 5 groups: eighty-three infants born from cardiac mothers; 98 from mothers that had toxemia; 54 of the mothers had diabetes mellitus; 40 were HIV positive and 140 had no diseases. INTERVENTION: All newborns had cord blood samples collected on filter paper at birth. MAIN MEASUREMENTS: TSH was measured from dried blood spots using a homemade immunofluorescence assay (sensitivity in dried blood spots = 0.1 mU/L). RESULTS: There was no significant difference in the mean TSH levels among the 5 groups. Moreover, TSH levels were around 5 mU/L in 48% of the newborns, indicating that our region is severely deficient in iodine. CONCLUSIONS: Our results indicate that primary TSH screening programs using cord blood are not affected by maternal diseases. We suggest that, besides its technical advantages over heel punctures with T4 primary approaches, neonatal screening using primary cord blood TSH may also be used as a monitoring tool for evaluation and control of iodine deficiency disorders (IDD).
L S Ward; I S Kunii; R M de Barros Maciel
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  118     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-21     Completed Date:  2000-12-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  144-7     Citation Subset:  IM    
Department of Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
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MeSH Terms
Acquired Immunodeficiency Syndrome
Congenital Hypothyroidism
Diabetes Mellitus
Fetal Blood / chemistry*
Follow-Up Studies
Heart Diseases
Hypothyroidism / diagnosis*
Infant, Newborn
Neonatal Screening
Pregnancy Complications*
Prospective Studies
Thyrotropin / blood*
Reg. No./Substance:

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