| Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. | |
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MedLine Citation:
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PMID: 21535074 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Abnormalities in thyroid state may affect development and function of the brain and result in mental retardation (MR). Thyroid parameters have not been systematically investigated in institutionalized MR subjects. The objective is to measure thyroid parameters in a novel cohort of 946 institutionalized subjects. Design: The TOP-R (Thyroid Origin of Psychomotor Retardation) study is a cross-sectional nation-wide multi-centre study. Patients: Subjects with unexplained MR. Results: The majority of the MR subjects had thyroid parameters within the reference range used in our laboratory. Antiepileptic drugs (AEDs) use affected thyroid hormones (T4: 102.1±1.2 vs. 83.9±1.2 nmol/L, P<1x10(-24) ; FT4: 18.0±0.2 vs. 16.1±0.2 pmol/L, P<1x10(-9) ; T3: 1.72±0.02 vs. 1.57±0.02 nmol/L, P<1x10(-9) ; and rT3: 0.37±0.01 vs. 0.27±0.01 nmol/L, P<1x10(-28) in subjects without vs. with AEDs). The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5.2% and 2.8%, respectively. Conclusions: We report thyroid parameters in a cohort of institutionalized subjects with MR. Our findings substantiate the fact that AEDs affect thyroid hormone levels. Future studies will be employed to investigate genetic causes of MR related to abnormalities in thyroid hormone homeostasis. |
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Authors:
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W Edward Visser; Yolanda B de Rijke; Hans van Toor; Theo J Visser |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-30 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine and Department of Clinical Chemistry Erasmus University Medical Centre Dr Molewaterplein 50 3015 GE Rotterdam1bThe Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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