Document Detail

Thyroid scintigraphy: an old tool is still the gold standard for an effective diagnosis of autonomously functioning thyroid nodules.
MedLine Citation:
PMID:  22732299     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with autonomously functioning thyroid nodules (AFTN) may not have an abnormal TSH value, particularly in iodine-deficient areas.
AIM: To verify the accuracy of TSH as screening test in detecting AFTN and to evaluate ultrasonographic features of thyroid nodules which have resulted autonomously functioning at thyroid scintigraphy (TS).
METHODS: Seventy-eight patients with nodular goiter, no marker of autoimmunity and at least one AFTN at TS were selected and divided in: Group 1 (no.=25) with TSH>0.35 IU/l, and Group 2 (no.=53) with TSH≤0.35 IU/l.
RESULTS: In Group1 the mean nodule diameter was 19.8±9.4 mm; 12 nodules were isoechoic, 2 hyperechoic, and 11 hypoechoic. Vascular pattern was type I in 4, type II in 6 and type III in 15 nodules. In Group 2 the mean nodule diameter was 28.6±14.2 mm; 27 nodules were isoechoic, 9 hyperechoic and 17 hypoechoic. Vascular pattern was type I in 14, type II in 15 and type III in 24 nodules.
CONCLUSION: In our study TSH alone was not able to identify AFTN in 32% of the patients. All hot nodules predominantly showed an isoechoic pattern with peri-intranodular vascularization; however, the presence of this pattern was not statistically significant. Moreover, we noticed a weak inverse correlation between the diameter of AFTN and TSH level. In conclusion, TS is the most sensitive tool to detect AFTN, allowing a precocious diagnosis even in the presence of a normal TSH value.
F Ianni; G Perotti; A Prete; R M Paragliola; M P Ricciato; C Carrozza; M Salvatori; A Pontecorvi; S M Corsello
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2012-06-25
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  36     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-05-06     Completed Date:  2013-11-14     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Middle Aged
Reference Standards
Thyroid Function Tests
Thyroid Gland / metabolism,  radionuclide imaging*
Thyroid Nodule / blood,  metabolism,  radionuclide imaging*
Thyrotropin / blood,  metabolism
Reg. No./Substance:

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