Document Detail


Thyroid receptor: roles in cancer.
MedLine Citation:
PMID:  19716314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The thyroid hormone receptors, encoded by the TRalpha and TRbeta genes, are ligand-dependent transcription factors that belong to the nuclear receptor superfamily. In addition to the role of these receptors in growth, development and metabolism, there is increasing evidence that they also inhibit transformation and act as tumor suppressors. Aberrant TR action, as well as receptor silencing, are common events in human cancer, and TRs also have an important role in tumor progression in experimental animal models, suggesting that these receptors constitute a novel therapeutic target in cancer. This review highlights recent studies on mechanisms by which loss of expression and/or function of these receptors results in a selective advantage for cellular transformation, tumor development and metastatic growth.
Authors:
Ana Aranda; Olaia Martínez-Iglesias; Lidia Ruiz-Llorente; Verónica García-Carpizo; Alberto Zambrano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-08-26
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  20     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-24     Citation Subset:  IM    
Affiliation:
Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain. aaranda@iib.uam.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transformation, Neoplastic / metabolism*
Gene Expression Regulation, Neoplastic / physiology*
Genes, erbA / physiology
Humans
Mice
Neoplasms / complications,  metabolism*,  physiopathology
Protein Isoforms
Receptors, Thyroid Hormone / metabolism*
Signal Transduction / physiology
Thyroid Diseases / complications,  metabolism*,  physiopathology
Chemical
Reg. No./Substance:
0/Protein Isoforms; 0/Receptors, Thyroid Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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