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Thyroid physiology and autoimmunity in pregnancy and after delivery.
MedLine Citation:
PMID:  21895480     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During pregnancy and after delivery, the maternal thyroid gland faces several metabolic, hemodynamic and immunologic changes. In this article we first summarize the current knowledge on the physiologic adaptation of the healthy thyroid to pregnancy, including variations of thyroid-stimulating hormone and free thyroid hormones, as well as variations of thyroid volume. Our second aim is to illustrate the background of thyroid autoimmunity in this period, which characteristically ameliorates during pregnancy and aggravates after delivery. Although rare during pregnancy, Graves' disease is the most frequent cause of hyperthyroidism, while Hashimoto's thyroiditis is the most frequent cause for hypothyroidism. Both types of thyroid dysfunction may lead to detrimental complications in mother and child and therefore timely recognition and treatment is essential. Postpartum autoimmunity most frequently exacerbates in the form of postpartum thyroiditis, which presents with diverse clinical presentations and may lead to permanent hypothyroidism.
Authors:
Simona Gaberšček; Katja Zaletel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  7     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  697-707     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, University Medical Centre Ljubljana, Zaloška 7, 1525 Ljubljana, Slovenia.
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