Document Detail


Thyroid peroxidase prevails over thyroid microsomal and thyroglobulin antibodies in thyroidal and nonthyroidal illnesses.
MedLine Citation:
PMID:  7519499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune thyroid disease is usually related to the presence of autoantibodies (TPO, TMA, TGA, TSH-R) in patients' sera. In this study the presence of autoantibodies in the sera of patients with thyroid disease, patients with end-stage renal disease and in several groups of euthyroid subjects have been evaluated (N = 217). The percentages of positive values detected in six groups ranged: 0-47%, 2-94% and 3-100% for TGA, TMA, and TPO, respectively. Autoantibodies were mostly present in the sera of patients with Hashimoto thyroiditis (TPO 100%, TMA 94%, TGA 47%), and sporadically in the control subjects (TPO 4%, TMA 2%, TGA 0%). Authors's results confirm the prevalence of TPO over TGA and TMA in the sera of all investigated groups. The authors did not find changes in ATA levels during methimazole therapy of their patients with Graves' disease. Some of serum autoantibodies were constantly present or absent in spite of remission.
Authors:
L Lukinac; Z Kusić; D Nöthig-Hus; P Kes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti     Volume:  48     ISSN:  1330-0164     ISO Abbreviation:  Acta Med Croatica     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-06     Completed Date:  1994-09-06     Revised Date:  2006-04-28    
Medline Journal Info:
Nlm Unique ID:  9208249     Medline TA:  Acta Med Croatica     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine and Oncology, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Autoantibodies / analysis*
Autoantigens / immunology*
Child
Child, Preschool
Female
Humans
Iodide Peroxidase / immunology*
Iron-Binding Proteins*
Kidney Failure, Chronic / immunology
Male
Middle Aged
Thyroglobulin / immunology*
Thyroid Diseases / immunology*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/Iron-Binding Proteins; 9010-34-8/Thyroglobulin; EC 1.11.1.7/TPO protein, human; EC 1.11.1.8/Iodide Peroxidase

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