Document Detail

Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease.
MedLine Citation:
PMID:  21951668     Owner:  NLM     Status:  In-Data-Review    
IgG4-related sclerosing disease (IgG4-RSD) is an inflammatory and fibrosing disorder characterized by lymphoplasmacytic inflammation with infiltration of various organs, including the pancreas, bile ducts, lung, kidney, and retroperitoneum. As for malignancy in IgG4-RSD, only limited literature is available. We report here a case of thyroid papillary carcinoma showing unique morphology in IgG4-RSD. Solid tumor nests were surrounded by dense IgG4-positive plasma cells and fibrosis at both the primary site and metastatic lymph nodes. In contrast the background thyroid showed focal lymphocytic thyroiditis. IgG4-related sclerosing sialadenitis and autoimmune pancreatitis were also diagnosed, and prednisolone treatment improved symptoms and serum IgG4 abnormality. To the best of our knowledge, this is the first documentation of a malignancy of the thyroid gland occurring in a background of IgG4-RSD. A brief review of the literature on the relationship between IgG4 and malignancy is included.
Masahiro Ito; Yuki Naruke; Yumi Mihara; Kenji So; Taiichiro Miyashita; Tomoki Origuchi; Masahiro Nakashima; Virginia Livolsi
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Publication Detail:
Type:  Journal Article     Date:  2011-07-11
Journal Detail:
Title:  Pathology international     Volume:  61     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  589-92     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Department of Pathology, National Nagasaki Medical Center Department of Otorhinolaryngology Department of Internal Medicine Nagasaki University School of Health Sciences Department of Tumor and Diagnostic Pathology, Nagasaki University School of Medicine, Nagasaki, Japan Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
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