Document Detail

Thyroid nodules with indeterminate cytology.
MedLine Citation:
PMID:  23150968     Owner:  NLM     Status:  In-Data-Review    
To the Editor: Alexander et al. (Aug. 23 issue)(1) report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the gene-expression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and a negative predictive value of 93%. Why the observed reduction in the performance of the gene-expression classifier, which was reported in their earlier study to have a sensitivity of 100% and a specificity of 73.3%?(2) With a high negative predictive value and a low positive predictive value, the gene-expression classifier . . .
José M Domínguez
Related Documents :
15242528 - Novel bidirectional vector strategy for amplification of therapeutic and reporter gene ...
21719428 - Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression...
14683448 - Biosafety of lentiviral vectors.
10088128 - Expanded-capacity adenoviral vectors--the helper-dependent vectors.
21244898 - In situ analysis of the cardiac muscle gene program during embryogenesis.
18763108 - Co-suppression in transgenic petunia hybrida expressing chalcone synthase a (chsa).
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1957-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thyroid nodules with indeterminate cytology.
Next Document:  Tofacitinib in active ulcerative colitis.