Document Detail

Thyroid involvement in Langerhans cell histiocytosis: a report of two cases and review of the literature.
MedLine Citation:
PMID:  17443347     Owner:  NLM     Status:  MEDLINE    
Langerhans cell histiocytosis (LCH) is a disorder with unclear etiology and pathogenesis characterized by abnormal clonal proliferation and accumulation of antigen presenting Langerhans' cells at various tissues and organs. Almost all organs or systems may be involved, and the prognosis depends on the involved sites and the presence of organ dysfunction. Thyroid tissue is a rarely affected site in children, and without histopathological evaluation it may be difficult to distinguish from other thyroid disorders because of the similar physical examination, laboratory and imaging findings. Here we report on two patients with histopathologically proven thyroid involvement of LCH. Additionally, the differential diagnosis of diffusely enlarged or multinodular thyroid glands in children is discussed, and a review of the literature of thyroid involvement in LCH is given. In the differential diagnosis of enlarged thyroid glands, especially in the presence of other endocrinological manifestations, LCH must be taken into consideration.
Begül Yağci; Nurgün Kandemir; Nalan Yazici; Bilgehan Yalçin; Ali Varan; Canan Akyüz; Münevver Büyükpamukçu
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-04-19
Journal Detail:
Title:  European journal of pediatrics     Volume:  166     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-07-20     Completed Date:  2008-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  901-4     Citation Subset:  IM    
Department of Pediatric Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Histiocytosis, Langerhans-Cell / complications*,  drug therapy,  pathology
Thyroid Diseases / etiology*,  pathology*,  surgery
Thyroid Gland / pathology

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