| Thyroid influence on the growth of hepatoma HW-165 in Wistar rats. | |
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MedLine Citation:
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PMID: 7337800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of a fast-growing hepatoma (HW-165) in normal euthyroid Wistar rats, was shown to be stimulated by daily injection of a dose of triiodo-L-thyronine (T3) as low as 1.5 microgram/100 g body weight. Administered to thyroidectomized rats, T3 completely restored the frequency of tumor initiation and accelerated the growth of the hepatoma, which had been considerably slowed down in hypothyroid rats. Contrary to other investigators, working on fast-growing Morris hepatomas, we did not observe any significant increase in the T3 level in the serum of hepatoma HW-165-bearing rats. Similarly, the tetra-iodo-L-thyronine (T4) levels were of the same order of magnitude in the blood of both normal and tumor host animals. The mitotic activity was reduced in hepatomas transplanted in hypothyroid rats and increased in tumors of T3-treated animals. These results support the assertion of Short (20) suggesting a relationship between the mitogenic effects of iodothyronines on the normal hepatocyte and on transplanted tumors of hepatic origin. |
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Authors:
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M Lemaire; W Baeyens; L de Saint-Georges; L Baugnet-Mahieu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedicine / [publiée pour l'A.A.I.C.I.G.] Volume: 34 ISSN: 0300-0893 ISO Abbreviation: Biomedicine Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-06-14 Completed Date: 1982-06-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0361342 Medline TA: Biomedicine Country: FRANCE |
Other Details:
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Languages: eng Pagination: 133-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects Liver Neoplasms, Experimental / pathology* Male Microscopy, Electron Mitosis / drug effects Neoplasm Transplantation Rats Rats, Inbred Strains Thyroidectomy Triiodothyronine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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