Document Detail

Thyroid hormones and thyroid disease in relation to perchlorate dose and residence near a superfund site.
MedLine Citation:
PMID:  22968349     Owner:  NLM     Status:  MEDLINE    
Perchlorate is a widely occurring contaminant, which can competitively inhibit iodide uptake and thus thyroid hormone production. The health effects of chronic low dose perchlorate exposure are largely unknown. In a community-based study, we compared thyroid function and disease in women with differing likelihoods of prior and current perchlorate exposure. Residential blocks were randomly selected from areas: (1) with potential perchlorate exposure via drinking water; (2) with potential exposure to environmental contaminants; and (3) neighboring but without such exposures. Eligibility included having lived in the area for ≥6 months and aged 20-50 years during 1988-1996 (during documented drinking water well contamination). We interviewed 814 women and collected blood samples (assayed for thyroid stimulating hormone and free thyroxine) from 431 interviewed women. Daily urine samples were assayed for perchlorate and iodide for 178 premenopausal women with blood samples. We performed multivariable regression analyses comparing thyroid function and disease by residential area and by urinary perchlorate dose adjusted for urinary iodide levels. Residential location and current perchlorate dose were not associated with thyroid function or disease. No persistent effect of perchlorate on thyroid function or disease was found several years after contaminated wells were capped.
Ellen B Gold; Benjamin C Blount; Marianne O'Neill Rasor; Jennifer S Lee; Udeni Alwis; Anup Srivastav; Kyoungmi Kim
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-09-12
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  23     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2013-12-09     Revised Date:  2014-02-03    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-408     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Drinking Water / adverse effects,  analysis
Environmental Exposure / adverse effects*
Hazardous Waste Sites*
Middle Aged
Perchlorates / adverse effects*,  analysis,  urine
Residence Characteristics
Thyroid Diseases / chemically induced*
Thyroid Hormones / blood*
Thyrotropin / blood
Thyroxine / blood
Young Adult
Grant Support
200-2007-M-19584//PHS HHS; 5P30ES005707/ES/NIEHS NIH HHS; P42 ES004699/ES/NIEHS NIH HHS; P42ES004699/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Drinking Water; 0/Perchlorates; 0/Thyroid Hormones; 9002-71-5/Thyrotropin; Q51BO43MG4/Thyroxine; VLA4NZX2P4/perchlorate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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