Document Detail


Thyroid hormones influence serum leptin concentrations in the rat.
MedLine Citation:
PMID:  9322968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin, the product of the ob gene, is secreted by adipocytes and has been shown to decrease appetite and increase energy expenditure. Leptin mRNA in adipocytes correlates with body wt, and serum leptin levels correlate with body fat. Alterations in thyroid status are frequently associated with changes in body wt. To evaluate the possible influence of thyroid status on the leptin system, we have measured serum leptin concentrations in thyroidectomized rats infused either with placebo, or with different doses of T4 (0.8 to 8.0 microg/100 g body wt per day) or T3 (0.25 to 2.0 microg/100 g body wt per day), covering a wide range of thyroid hormone concentrations, from overt hypothyroidism to hyperthyroidism. Intact animals infused with placebo were used as euthyroid controls. Infusion of T4 or T3 into thyroidectomized rats resulted in a decrease in serum leptin levels with respect to the thyroidectomized animals infused with placebo. When compared to the control group, serum leptin levels were decreased in the groups infused with the higher T4 and T3 doses, and tended to be elevated in the thyroidectomized animals infused with placebo. The leptin/body wt ratio was markedly increased in thyroidectomized rats infused with placebo, and decreased in the animals infused with the higher thyroid hormone doses. In conclusion, thyroid hormones exert a negative influence on serum leptin concentrations, which is greater than expected by the changes in body wt The precise mechanism of this influence remains to be elucidated.
Authors:
H F Escobar-Morreale; F Escobar del Rey; G Morreale de Escobar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  138     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4485-8     Citation Subset:  AIM; IM    
Affiliation:
Unidad de Endocrinología Molecular, Instituto de Investigaciones Biomédicas, CSIC & UAM, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Body Weight / physiology
Dose-Response Relationship, Drug
Female
Hyperthyroidism / blood
Hypothyroidism / blood
Leptin
Proteins / analysis,  metabolism*
Rats
Rats, Wistar
Thyroid Gland / drug effects,  physiology
Thyroid Hormones / pharmacology*
Thyroidectomy
Thyrotropin / blood
Thyroxine / pharmacology
Triiodothyronine / pharmacology
Chemical
Reg. No./Substance:
0/Leptin; 0/Proteins; 0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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