| Thyroid hormones in relation to urinary metabolites of non-persistent insecticides in men of reproductive age. | |
| | |
MedLine Citation:
|
PMID: 16584866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human exposure to contemporary-use insecticides is widespread, but effects of exposure on human endocrine function have gone largely untested to date. Samples of urine and blood were collected concurrently from 322 adult men between the years 2000 and 2003. Urine samples were analyzed for 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1-napththol (1N), a metabolite of carbaryl and naphthalene. Serum samples were analyzed for free T(4), total T(3), and thyroid stimulating hormone (TSH). There was an association between TCPY and TSH, where an interquartile range (IQR) increase in TCPY was associated with a 9% (95% confidence interval 0-18%) increase in TSH. There was also a suggestive inverse association between TCPY and free T(4). There were no associations between 1N and thyroid hormones. Environmental exposure to chlorpyrifos, chlorpyrifos-methyl, or its metabolite TCPY may be associated with altered thyroid function in human males. |
| | |
Authors:
|
John D Meeker; Dana B Barr; Russ Hauser |
Related Documents
:
|
16219356 - Fate of manganese associated with the inhalation of welding fumes: potential neurologic... 18840936 - Hepatic effects among workers exposed to ethylene glycol monoethyl ether acetate. 1949056 - Benzo-a-pyrene: environmental partitioning and human exposure. 20836066 - Chronic exposure to fluoxetine (prozac) causes developmental delays in rana pipiens lar... 9632466 - Teat massage after milk ingestion in domestic piglets: an example of honest begging? 1614946 - Response to angiotensin ii after selective lesioning of brain regions believed to be in... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-04-03 |
Journal Detail:
|
Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 22 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-15 Completed Date: 2006-11-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
|
Languages: eng Pagination: 437-42 Citation Subset: IM |
Affiliation:
|
Department of Environmental Health Sciences, University of Michigan, School of Public Health, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109, USA. meekerj@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Fertility / drug effects* Humans Insecticides / adverse effects*, metabolism, urine* Male Naphthols / urine Pyridones / urine Retrospective Studies Thyroid Hormones / blood* Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood |
| Grant Support | |
ID/Acronym/Agency:
|
ES00002/ES/NIEHS NIH HHS; ES09718/ES/NIEHS NIH HHS; T32 ES07069/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Insecticides; 0/Naphthols; 0/Pyridones; 0/Thyroid Hormones; 6515-38-4/3,5,6-trichloro-2-pyridinol; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 90-15-3/1-naphthol; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The detection of oesophageal adenocarcinoma by serum microsatellite analysis.
Next Document: Detection of cytotoxic CD13-specific autoantibodies in sera from patients with ulcerative colitis an...