Document Detail

Thyroid hormones in relation to urinary metabolites of non-persistent insecticides in men of reproductive age.
MedLine Citation:
PMID:  16584866     Owner:  NLM     Status:  MEDLINE    
Human exposure to contemporary-use insecticides is widespread, but effects of exposure on human endocrine function have gone largely untested to date. Samples of urine and blood were collected concurrently from 322 adult men between the years 2000 and 2003. Urine samples were analyzed for 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1-napththol (1N), a metabolite of carbaryl and naphthalene. Serum samples were analyzed for free T(4), total T(3), and thyroid stimulating hormone (TSH). There was an association between TCPY and TSH, where an interquartile range (IQR) increase in TCPY was associated with a 9% (95% confidence interval 0-18%) increase in TSH. There was also a suggestive inverse association between TCPY and free T(4). There were no associations between 1N and thyroid hormones. Environmental exposure to chlorpyrifos, chlorpyrifos-methyl, or its metabolite TCPY may be associated with altered thyroid function in human males.
John D Meeker; Dana B Barr; Russ Hauser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-04-03
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  22     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-15     Completed Date:  2006-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Department of Environmental Health Sciences, University of Michigan, School of Public Health, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109, USA.
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MeSH Terms
Age Factors
Fertility / drug effects*
Insecticides / adverse effects*,  metabolism,  urine*
Naphthols / urine
Pyridones / urine
Retrospective Studies
Thyroid Hormones / blood*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Grant Support
Reg. No./Substance:
0/Insecticides; 0/Naphthols; 0/Pyridones; 0/Thyroid Hormones; 6515-38-4/3,5,6-trichloro-2-pyridinol; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 90-15-3/1-naphthol; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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