Document Detail

Thyroid hormones in the pathogenesis and treatment of obesity.
MedLine Citation:
PMID:  12007527     Owner:  NLM     Status:  MEDLINE    
Thyroid hormones (TH) are potent modulators of adaptive thermogenesis and can potentially contribute to development of obesity. The decrease of T(3) in association with reduction of calorie intake is centrally regulated via decreases in leptin and melanocortin concentrations and peripherally via a decrease in deiodinase activity, all aimed at protein and energy sparing. The use of TH in the treatment of obesity is hardly justified except in cases of elevated thyrotropin (TSH) with low/normal T(3) and T(4) and/or a low T(3) or T'(3)/T(4) or a high TSH/T(3) ratio. TH treatment with small doses of T(3) can also be exceptionally applied in obese patients resistant to dietary therapy who are taking beta-adrenergic blockers or with obesity developed after cessation of cigarette smoking and with hyperlipidemia and a concomitant high thryrotropin/T(3) ratio. Supplementation with Se(2+) and Zn(2+) may be tried along with more severe calorie restriction to prevent decline of T(3).
Marcin Krotkiewski
Related Documents :
11087657 - Genetic evidence for obesity loci involved in the regulation of body fat distribution i...
20842147 - Obesity-related renal damage: changing diet to avoid progression.
20514927 - Role of excitatory amino acid input in rostral ventrolateral medulla neurons in rats wi...
20368177 - Gut check: testing a role for the intestinal microbiome in human obesity.
21477407 - Dietary glycaemic load and intakes of carbohydrates, fats and proteins in 1040 hospital...
9078537 - Neuropsychologic functions of early treated patients with phenylketonuria, on and off d...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pharmacology     Volume:  440     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-14     Completed Date:  2002-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-98     Citation Subset:  IM    
Department of Rehabilitation Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Weight / physiology
Eating / physiology
Hyperthyroidism / metabolism
Hypothyroidism / metabolism
Leptin / metabolism
Models, Biological
Obesity / metabolism*,  physiopathology,  therapy*
Thyroid Hormones / metabolism*
Reg. No./Substance:
0/Leptin; 0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Targets for therapy of the painful bladder.
Next Document:  beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.