Document Detail

Thyroid hormones and the control of cell proliferation or cell differentiation: paradox or duality?
MedLine Citation:
PMID:  19737599     Owner:  NLM     Status:  MEDLINE    
Amphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control diverse cellular processes depending on the tissue context. This point is also reinforced by a recent accumulation of evidence. For example, thyroid hormones and their nuclear receptor TRs have been described to function in different systems in synergy and/or in antagonism with other signaling pathways. This interaction helps explain their pleiotropic roles. This review summarizes the most important advances in this field, focusing in particular on the key action of thyroid hormones in controlling the balance between the processes of cell proliferation and cell differentiation in a few organs, with special attention paid to the intestine. We highlight similarities between the cellular and molecular events occurring during postnatal intestinal maturation at metamorphosis in amphibians, and comparable events observed at weaning in mice.
Elsa Kress; Jacques Samarut; Michelina Plateroti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-06
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  313     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  36-49     Citation Subset:  IM    
Institut de G??nomique Fonctionnelle de Lyon, Universit?? de Lyon, Universit?? Lyon 1, CNRS, INRA, Ecole Normale Sup??rieure de Lyon, 46 all??e d'Italie, 69364 Lyon Cedex 07, France.
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MeSH Terms
Amphibians / anatomy & histology,  physiology
Cell Differentiation / physiology*
Cell Proliferation*
Central Nervous System / physiology
Gene Expression Regulation
Intestines / cytology,  physiology
Larva / metabolism
Metamorphosis, Biological / physiology
Receptors, Thyroid Hormone / metabolism
Skin / metabolism,  pathology
Thyroid Hormones / metabolism*
Tissue Distribution
beta Catenin / metabolism
Reg. No./Substance:
0/Receptors, Thyroid Hormone; 0/Thyroid Hormones; 0/beta Catenin

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