| Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. | |
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MedLine Citation:
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PMID: 22684107 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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For more than a century, thyroid hormones (THs) have been known to exert powerful catabolic effects, leading to weight loss. Although much has been learned about the molecular mechanisms used by TH receptors (TRs) to regulate gene expression, little is known about the mechanisms by which THs increase oxidative metabolism. Here, we report that TH stimulation of fatty acid β-oxidation is coupled with induction of hepatic autophagy to deliver fatty acids to mitochondria in cell culture and in vivo. Furthermore, blockade of autophagy by autophagy-related 5 (ATG5) siRNA markedly decreased TH-mediated fatty acid β-oxidation in cell culture and in vivo. Consistent with this model, autophagy was altered in livers of mice expressing a mutant TR that causes resistance to the actions of TH as well as in mice with mutant nuclear receptor corepressor (NCoR). These results demonstrate that THs can regulate lipid homeostasis via autophagy and help to explain how THs increase oxidative metabolism. |
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Authors:
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Rohit Anthony Sinha; Seo-Hee You; Zhou Jin; Mobin M Siddique; Boon-Huat Bay; Xuguang Zhu; Martin L Privalsky; Sheue-Yann Cheng; Robert D Stevens; Scott A Summers; Christopher B Newgard; Mitchell A Lazar; Paul M Yen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-11 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: - ISSN: 1558-8238 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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