Document Detail


Thyroid hormone regulates renocortical COX-2 and PGE2 expression in the late gestation fetal sheep.
MedLine Citation:
PMID:  18579848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclooxygenase 2 (COX-2) is important for development of the fetal kidney. Precisely how renal COX-2 expression is regulated in fetal life is unclear. The hypothesis that thyroid hormone positively regulates COX-2 and PGE(2) levels in the late gestation fetal kidney cortex was tested. Sham, thyroidectomized (TX), and TX + thyroid hormone replacement (R) fetal sheep were studied. TX was performed at 120 days gestational age (dGA). TX + R fetuses were continuously infused with thyroxine from 3 days after surgery until study completion. Fetal kidney cortex was obtained at 137 dGA for measurement of renal cyclooxygenase type-2 (COX-2) protein and PGE(2) metabolites. Renocortical COX-2 and PGE(2) levels were significantly lower in TX compared with sham and TX + R fetuses. There were no differences between sham and TX + R fetuses. These findings demonstrate that thyroid hormone positively regulates renal COX-2 and PGE(2) expression in the late gestation fetal sheep kidney.
Authors:
Luke C Carey; Nancy K Valego; Kai Chen; James C Rose
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-08-26     Revised Date:  2010-10-05    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  598-603     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. lcarey@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclooxygenase 2 / biosynthesis*
Dinoprostone / biosynthesis*
Female
Fetus
Hormone Replacement Therapy
Kidney Cortex / embryology*,  enzymology,  metabolism*
Pregnancy
Sheep
Thyroxine / blood,  metabolism*,  pharmacology
Triiodothyronine / blood
Grant Support
ID/Acronym/Agency:
HD17644/HD/NICHD NIH HHS; R01 HD017644-25/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
363-24-6/Dinoprostone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC 1.14.99.1/Cyclooxygenase 2

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