Document Detail

Thyroid hormone regulates renocortical COX-2 and PGE2 expression in the late gestation fetal sheep.
MedLine Citation:
PMID:  18579848     Owner:  NLM     Status:  MEDLINE    
Cyclooxygenase 2 (COX-2) is important for development of the fetal kidney. Precisely how renal COX-2 expression is regulated in fetal life is unclear. The hypothesis that thyroid hormone positively regulates COX-2 and PGE(2) levels in the late gestation fetal kidney cortex was tested. Sham, thyroidectomized (TX), and TX + thyroid hormone replacement (R) fetal sheep were studied. TX was performed at 120 days gestational age (dGA). TX + R fetuses were continuously infused with thyroxine from 3 days after surgery until study completion. Fetal kidney cortex was obtained at 137 dGA for measurement of renal cyclooxygenase type-2 (COX-2) protein and PGE(2) metabolites. Renocortical COX-2 and PGE(2) levels were significantly lower in TX compared with sham and TX + R fetuses. There were no differences between sham and TX + R fetuses. These findings demonstrate that thyroid hormone positively regulates renal COX-2 and PGE(2) expression in the late gestation fetal sheep kidney.
Luke C Carey; Nancy K Valego; Kai Chen; James C Rose
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-08-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  598-603     Citation Subset:  IM    
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MeSH Terms
Cyclooxygenase 2 / biosynthesis*
Dinoprostone / biosynthesis*
Hormone Replacement Therapy
Kidney Cortex / embryology*,  enzymology,  metabolism*
Thyroxine / blood,  metabolism*,  pharmacology
Triiodothyronine / blood
Grant Support
Reg. No./Substance:
06LU7C9H1V/Triiodothyronine; EC 2; K7Q1JQR04M/Dinoprostone; Q51BO43MG4/Thyroxine

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