Document Detail


Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer.
MedLine Citation:
PMID:  23275305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MATERIALS AND METHODS: The expression of the combined antibody TRalpha1 and 2 and TRalpha1 or 2 alone as well as the expression of combined TRbeta1 and 2 and TRbeta1 or 2 alone was investigated with specific monoclonal or polyclonal antibodies in 82 patients. All patients presented with a first diagnosis of sporadic breast cancer. The ABC method was used for staining and staining intensities were analyzed using the IRS score.
RESULTS: Both TRalpha and TRbeta were expressed in the nuclei of breast cancer cells. In 24% (28/78) of the slides TRalpha1 and 2 IRS was positive. Immunopositivity for TRalpha1 was found in 55/78 slides, for TRalpha 2 in 54/79 slides (71 and 68%, respectively). The expression of TRbeta1 and 2 showed a positive detection in 33/77 (43%) of the slides, for TRbeta1 it was 43/79 (54%), for TRbeta2 60/76 (79%). Significant correlations of the expression of TRs - especially TRalpha2 - were found with further prognostic histopathological parameters such as tumor size, axillary lymph node involvement, grading and hormone receptor status. Multivariate analysis showed a trend for TRalpha2 as an independent predictor of disease-free and overall survival.
DISCUSSION: Our results revealed specific alterations in the expression of TRs - especially of TRalpha2 - in breast cancer patients, suggesting it as a marker with possible prognostic validity.
Authors:
Nina Ditsch; Bettina Toth; Isabelle Himsl; Miriam Lenhard; Robert Ochsenkühn; Klaus Friese; Doris Mayr; Udo Jeschke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  28     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-06-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  227-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Breast Neoplasms / diagnosis,  metabolism*,  mortality
Carcinoma, Ductal, Breast / diagnosis,  metabolism*,  mortality
Cell Nucleus / metabolism,  pathology
Female
Follow-Up Studies
Humans
Immunohistochemistry / methods
Kaplan-Meier Estimate
Middle Aged
Multivariate Analysis
Prognosis
Retrospective Studies
Survival Rate
Thyroid Hormone Receptors alpha / metabolism*
Thyroid Hormone Receptors beta / metabolism*
Tumor Markers, Biological / metabolism*
Chemical
Reg. No./Substance:
0/Thyroid Hormone Receptors alpha; 0/Thyroid Hormone Receptors beta; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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