| Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil - in vivo evidence for crosstalking mechanisms. | |
| | |
MedLine Citation:
|
PMID: 21752938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
n-3 polyunsaturated fatty acids (n-3 PUFA) from fish oil exert important lipid-lowering effects, an effect also ascribed to thyroid hormones (TH) and to TH receptor beta1 (TRβ1) specific agonists. N-3 PUFA effects are mediated by nuclear receptors, such as Proliferator Peroxisome Activated Receptor (PPAR) and others. Here we investigated a role for TH signaling in n-3 PUFA effects. Euthyroid and hypothyroid adult rats (methimazole-treated for five weeks) received fish oil (FO) or soybean oil (control) by oral administration during three weeks. In euthyroid rats, FO treatment reduced serum triglycerides and cholesterol, diminished body fat and increased protein content of the animals. In addition, FO-treated rats exhibited higher liver expression of TRβ1 and of mitochondrial glicerophosphate dehydrogenase(mGPD), at protein and mRNA levels, but no alteration of Glutatione S-Transferase(GST) or Type 1 Deiodinase(D1). In hypothyroid condition, fish oil induced reduction in serum cholesterol and increase in body protein content, but lost the ability to reduce triglycerides and body fat, and to induce TRβ1 and mGDP expression. FO did not change PPARα liver abundance regardless of thyroid state, however, hypothyroidism led to a marked increase in PPARα liver content, but did not alter TRβ1 or TRα expression. The data suggest that part of the effects of n-3 PUFA from fish oil on lipid metabolism are dependent on TH signaling in specific steps and together with the marked up-regulation of PPARα in liver of hypothyroid rats suggest important in vivo consequences of the crosstalking between those fatty acids and TH pathways in liver metabolism. |
| | |
Authors:
|
Luana L Souza; Aline Cordeiro; Lorraine Soares Oliveira; Gabriela Silva Monteiro Paula; Larissa Costa Faustino; Tania Maria Ortiga-Carvalho; Karen J Oliveira; Carmen Cabanelas Pazos-Moura |
Related Documents
:
|
8020168 - Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as gen... 3683188 - L-carnitine treatment in the hyperlipidemic rabbit. 21441388 - Pre-cure freezing effect on physicochemical, texture and sensory characteristics of ibe... 14568258 - Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of... 7410268 - Determining effects of monensin on energy value of corn silage diets for beef cattle by... 9194768 - The effects of folic acid supplementation on plasma total homocysteine are modulated by... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-14 |
Journal Detail:
|
Title: The Journal of endocrinology Volume: - ISSN: 1479-6805 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
L Souza, Instituto de Biofisica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in...
Next Document: Sun safety measures among construction workers in Britain.