Document Detail

Thyroid hormone concentrations in preterm infants born to pre-eclamptic women with placental insufficiency.
MedLine Citation:
PMID:  9512206     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to compare thyroid function in preterm infants born to women with placental insufficiency (n = 15) and those born to women without placental insufficiency (n = 13). Gestational ages ranged between 28 and 33 weeks. Concentrations of free thyroxine (FT4), thyrotropin (TSH), triiodothyronine (T3) and reverse T3 (rT3) were measured by radioimmmunoassays in cord blood and on d 1, 3, 5, 7, 14 and 21. Infants born to the women with placental insufficiency had significantly lower mean FT4 (p = 0.001), TSH (p = 0.002) and rT3 values (p = 0.025) in cord blood, and higher rT3 values on d 5 (p = 0.019) and d 7 (p = 0.025). The following conclusions were reached: (i) preterm infants born to pre-eclamptic women with placental insufficiency have intact hypothalamic-pituitary-thyroid axes; (ii) compared to preterm infants born to healthy women, preterm infants born to pre-eclamptic women with placental insufficiency have lower FT4 and TSH concentrations before birth and (iii) elevated rT3 concentrations after birth, suggesting a temporarily impaired hepatic type 1 deiodination process.
W P Fetter; C M Waals-Van de Wal; J Van Eyck; G Samson; J J Bongers-Schokking
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  87     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Department of Pediatrics, Sophia Hospital, Zwolle, The Netherlands.
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MeSH Terms
Birth Weight
Chi-Square Distribution
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Placental Insufficiency / blood*,  etiology
Pre-Eclampsia / blood*,  etiology
Statistics, Nonparametric
Thyroid Hormones / blood*
Reg. No./Substance:
0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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