| Thyroid hormone concentrations in preterm infants born to pre-eclamptic women with placental insufficiency. | |
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MedLine Citation:
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PMID: 9512206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare thyroid function in preterm infants born to women with placental insufficiency (n = 15) and those born to women without placental insufficiency (n = 13). Gestational ages ranged between 28 and 33 weeks. Concentrations of free thyroxine (FT4), thyrotropin (TSH), triiodothyronine (T3) and reverse T3 (rT3) were measured by radioimmmunoassays in cord blood and on d 1, 3, 5, 7, 14 and 21. Infants born to the women with placental insufficiency had significantly lower mean FT4 (p = 0.001), TSH (p = 0.002) and rT3 values (p = 0.025) in cord blood, and higher rT3 values on d 5 (p = 0.019) and d 7 (p = 0.025). The following conclusions were reached: (i) preterm infants born to pre-eclamptic women with placental insufficiency have intact hypothalamic-pituitary-thyroid axes; (ii) compared to preterm infants born to healthy women, preterm infants born to pre-eclamptic women with placental insufficiency have lower FT4 and TSH concentrations before birth and (iii) elevated rT3 concentrations after birth, suggesting a temporarily impaired hepatic type 1 deiodination process. |
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Authors:
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W P Fetter; C M Waals-Van de Wal; J Van Eyck; G Samson; J J Bongers-Schokking |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 87 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-02 Completed Date: 1998-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 186-90 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Sophia Hospital, Zwolle, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Chi-Square Distribution Female Gestational Age Humans Infant, Newborn Infant, Premature / blood* Placental Insufficiency / blood*, etiology Pre-Eclampsia / blood*, etiology Pregnancy Radioimmunoassay Statistics, Nonparametric Thyroid Hormones / blood* |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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