Document Detail

Thyroid hormone and the cardiovascular system.
MedLine Citation:
PMID:  2189307     Owner:  NLM     Status:  MEDLINE    
To understand the pathophysiology of thyroid heart disease, it is necessary to recognize that thyroid hormone has effects on both the peripheral circulation and the myocardium. One of the earliest responses to thyroid hormone administration is a decline in systemic vascular resistance and an increase in cardiac output and cardiac contractility. In many ways, this response is similar to the cardiovascular response to exercise and is associated with increased left ventricular work. The majority of cardiac adaptations to changes in thyroid function are physiologic; however, certain patients do demonstrate clinical evidence of cardiac disease. Atrial arrhythmias, limitations in exercise tolerance, and congestive heart failure are reported to occur as a result of hyperthyroidism and are more common in older patients. Thyroid hormone also plays an important role in the regulation of blood pressure. Diastolic hypertension is a common accompaniment of hypothyroidism. By understanding the mechanisms by which thyroid hormone affects both the peripheral circulation as well as the myocardium, it is possible to predict the clinical response to the treatment of various thyroid disease states.
I Klein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  88     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  AIM; IM    
Department of Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030.
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MeSH Terms
Heart / drug effects*
Heart Diseases / etiology
Hemodynamics / drug effects*
Myocardial Contraction / drug effects
Thyroid Diseases / complications
Thyroxine / pharmacology*
Triiodothyronine / pharmacology*
Grant Support
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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