| Thyroid hormone as a therapeutic option for treating ischaemic heart disease: from early reperfusion to late remodelling. | |
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MedLine Citation:
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PMID: 19951746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyroid hormone (TH), apart from its "classical" actions on cardiac contractility and heart rhythm, appears to regulate various intracellular signalling pathways related to response to stress and cardiac remodelling. There is now accumulating experimental and clinical evidence showing a beneficial effect of TH on limiting myocardial ischaemic injury, preventing/reversing post infarction cardiac remodelling and improving cardiac hemodynamics. Thyroid analogs have already been developed and may allow TH use in clinical practice. However, the efficacy of TH in the treatment of cardiac diseases is now awaiting to be tested in large clinical trials. |
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Authors:
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Constantinos Pantos; Iordanis Mourouzis; Dennis V Cokkinos |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-11-29 |
Journal Detail:
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Title: Vascular pharmacology Volume: 52 ISSN: 1879-3649 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 157-65 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pharmacology, University of Athens, School of Medicine, 75 Mikras Asias Ave., 11527 Goudi, Athens, Greece. cpantos@cc.uoa.gr, cpantos@med.uoa.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hemodynamics / drug effects Humans Myocardial Contraction / physiology Myocardial Ischemia / drug therapy*, physiopathology Signal Transduction / drug effects Thyroid Hormones / metabolism, therapeutic use* Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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