Document Detail


Thyroid hormone as a therapeutic option for treating ischaemic heart disease: from early reperfusion to late remodelling.
MedLine Citation:
PMID:  19951746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid hormone (TH), apart from its "classical" actions on cardiac contractility and heart rhythm, appears to regulate various intracellular signalling pathways related to response to stress and cardiac remodelling. There is now accumulating experimental and clinical evidence showing a beneficial effect of TH on limiting myocardial ischaemic injury, preventing/reversing post infarction cardiac remodelling and improving cardiac hemodynamics. Thyroid analogs have already been developed and may allow TH use in clinical practice. However, the efficacy of TH in the treatment of cardiac diseases is now awaiting to be tested in large clinical trials.
Authors:
Constantinos Pantos; Iordanis Mourouzis; Dennis V Cokkinos
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-11-29
Journal Detail:
Title:  Vascular pharmacology     Volume:  52     ISSN:  1879-3649     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pharmacology, University of Athens, School of Medicine, 75 Mikras Asias Ave., 11527 Goudi, Athens, Greece. cpantos@cc.uoa.gr, cpantos@med.uoa.gr
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MeSH Terms
Descriptor/Qualifier:
Animals
Hemodynamics / drug effects
Humans
Myocardial Contraction / physiology
Myocardial Ischemia / drug therapy*,  physiopathology
Signal Transduction / drug effects
Thyroid Hormones / metabolism,  therapeutic use*
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Thyroid Hormones

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