Document Detail


Thyroid hormone analog, diiodothyropropionic acid (DITPA), exerts beneficial effects on chamber and cellular remodeling in cardiomyopathic hamsters.
MedLine Citation:
PMID:  17612639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diiodothyropropionic acid (DITPA) is a thyroid hormone analog that is currently in phase II clinical trials. However, there have not been any studies to comprehensively analyze its effect on myocyte morphology. In addition, long-term studies with DITPA have not been done. This study compares the effects of DITPA with L-thyroxine (T4) on chamber remodeling, cardiac function, cellular morphology, cardiac blood flow, and protein expression. Normal and cardiomyopathic hamsters were treated with T4 or DITPA for 2 months. At the end of the treatment, echos, hemodynamics, coronary blood flow, cell morphology, and protein expression data were collected. Both T4 and DITPA treatment reduced chamber diameter during diastole, suggesting attenuated chamber dilatation in cardiomyopathic hamsters. Wall thickness also tended to increase, which was supported by cell morphology data in which DITPA significantly increased cross-sectional growth of myocytes specifically in the minor dimension, which is oriented transmurally. T4 and DITPA also increased myocardial blood flow both at baseline and after maximal dilation. This suggests there was increased angiogenesis or reduced loss of arterioles. Both T4 and DITPA had beneficial effects on chamber remodeling, which was most likely due to beneficial changes in cell shape and improved vascular supply.
Authors:
James A Kuzman; Yida Tang; Kathryn A Vogelsang; Suleman Said; Brent E Anderson; Eugene Morkin; A Martin Gerdes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  85     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-10-16     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, Sanford Research, University of South Dakota, 1100 East 21st Street, Sioux Falls, SD 57105, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiomyopathies / drug therapy*,  metabolism,  pathology,  physiopathology
Cardiotonic Agents / therapeutic use*
Coronary Circulation / drug effects
Cricetinae
Diiodothyronines / therapeutic use*
Heart / drug effects,  physiology
Heart Rate / drug effects
Male
Myocytes, Cardiac / drug effects,  pathology
Propionic Acids / therapeutic use*
Regional Blood Flow / drug effects
Thyrotropin / blood
Thyroxine / pharmacology
Triiodothyronine / blood
Ventricular Remodeling / drug effects*
Grant Support
ID/Acronym/Agency:
P20 RR017662/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Diiodothyronines; 0/Propionic Acids; 1158-10-7/3,5-diiodothyropropionic acid; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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