Document Detail

Thyroid hormone action in chronic kidney disease.
MedLine Citation:
PMID:  18769220     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Chronic kidney disease is characterized by multiple abnormalities in the thyroid hormone physiology. In the present review, we will briefly discuss the effects of uremia on thyroid hormone synthesis, metabolism, transport, and action. RECENT FINDINGS: Uremic toxins have been shown to interfere at various levels of the thyroid hormone action, including thyroid hormone transport across plasma membrane and thyroid hormone receptor activity. These abnormalities could explain the resistance to thyroid hormone action in uremia, at least in some tissues. SUMMARY: The pathogenesis of thyroid axis abnormalities in uremia is incompletely understood, and its clinical significance remains unclear. The increasing prevalence of chronic kidney disease underscores the need for further efforts to understand the metabolic consequences of uremia and address questions such as the impact of thyroid hormone therapy.
Angélica Amorim Amato; Guilherme Martins Santos; Francisco de Assis Rocha Neves
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  15     ISSN:  1752-2978     ISO Abbreviation:  -     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Molecular Pharmacology Laboratory, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
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MeSH Terms
Kidney Failure, Chronic / drug therapy,  metabolism*
Models, Biological
Signal Transduction
Thyroid Hormones / metabolism*
Triiodothyronine / therapeutic use
Uremia / complications,  metabolism
Reg. No./Substance:
0/Thyroid Hormones; 6893-02-3/Triiodothyronine

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