Document Detail

Thyroid hormone action in cerebellum and cerebral cortex development.
MedLine Citation:
PMID:  21765985     Owner:  NLM     Status:  In-Data-Review    
Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3',5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.
Fabrice Chatonnet; Frédéric Picou; Teddy Fauquier; Frédéric Flamant
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Publication Detail:
Type:  Journal Article     Date:  2011-06-16
Journal Detail:
Title:  Journal of thyroid research     Volume:  2011     ISSN:  2042-0072     ISO Abbreviation:  J Thyroid Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101536655     Medline TA:  J Thyroid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145762     Citation Subset:  -    
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR CNRS 5242, 46 allée d'Italie, 69364 Lyon Cedex 07, France.
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