Document Detail

Thyroid hormone (T3)-induced up-regulation of voltage-activated sodium current in cultured postnatal hippocampal neurons requires secretion of soluble factors from glial cells.
MedLine Citation:
PMID:  19460859     Owner:  NLM     Status:  MEDLINE    
We have previously shown that treatment with the thyroid hormone T(3) increases the voltage-gated Na(+)current density (Nav-D) in hippocampal neurons from postnatal rats, leading to accelerated action potential upstrokes and increased firing frequencies. Here we show that the Na(+) current regulation depends on the presence of glial cells, which secrete a heat-instable soluble factor upon stimulation with T(3). The effect of conditioned medium from T(3)-treated glial cells was mimicked by basic fibroblast growth factor (bFGF), known to be released from cerebellar glial cells after T(3) treatment. Neutralization assays of astrocyte-conditioned media with anti-bFGF antibody inhibited the regulation of the Nav-D by T(3). This suggests that the up-regulation of the neuronal sodium current density by T(3) is not a direct effect but involves bFGF release and satellite cells. Thus glial cells can modulate neuronal excitability via secretion of paracrinely acting factors.
Vanessa Niederkinkhaus; Romy Marx; Gerd Hoffmann; Irmgard D Dietzel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-21
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  23     ISSN:  1944-9917     ISO Abbreviation:  Mol. Endocrinol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-16     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1494-504     Citation Subset:  IM    
Department of Molecular Neurobiochemistry, Ruhr-University Bochum, NC7-170, Universitätsstrasse 150, D-44780 Bochum, Germany.
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MeSH Terms
Astrocytes / cytology
Fibroblast Growth Factor 2 / metabolism
Hippocampus / metabolism*
Models, Biological
Neuroglia / metabolism*
Neurons / metabolism*
Patch-Clamp Techniques
Rats, Wistar
Sodium / metabolism*
Sodium Channels / metabolism
Triiodothyronine / metabolism*
Reg. No./Substance:
0/Sodium Channels; 103107-01-3/Fibroblast Growth Factor 2; 6893-02-3/Triiodothyronine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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