Document Detail

Thyroid gland pigmentation and minocycline therapy.
MedLine Citation:
PMID:  6435454     Owner:  NLM     Status:  MEDLINE    
Thyroid pigments in black thyroid glands from minocycline-treated patients were compared by light and electron microscopy, histochemistry, and energy-dispersive x-ray analysis with minocycline-induced pigment in thyroid glands of laboratory animals, and with naturally occurring lipofuscins in untreated laboratory animals and humans. All thyroid samples examined contained nonbirefringent, Schmorl-positive pigment. However, the pigments in black thyroids from minocycline-treated patients resembled lipofuscins of untreated humans since both fluoresced and were Ziehl-Neelsen- and Sudan IV-positive. Minocycline induced pigment in rats was nonfluorescent and Ziehl-Neelsen- and Sudan IV-negative. Ultrastructurally, pigments in black thyroid glands of minocycline-treated humans resembled lipofuscins in untreated humans, and initial elemental analyses yielded similar spectra. Repeated analyses of the most electron-dense pigment deposits yielded spectra that resembled those of minocycline-induced pigment in laboratory animals-ie, both contained calcium. Black thyroid glands associated with minocycline administration contained predominantly lipofuscins with a small amount of another, possibly minocycline-related pigment. The absence of functional changes in patients and animals given minocycline suggests that discoloration of the thyroid gland associated with minocycline administration is innocuous. This is further supported by the lack of documented changes in thyroid physiology in patients that have received tetracyclines for a variety of indications in the last 30-odd years since their introduction to therapy.
G Gordon; B M Sparano; A W Kramer; R G Kelly; M J Iatropoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  117     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-05     Completed Date:  1984-11-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-109     Citation Subset:  AIM; IM    
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MeSH Terms
Electron Probe Microanalysis
Guinea Pigs
Lipofuscin / analysis*
Microscopy, Electron
Middle Aged
Minocycline / adverse effects*
Pigmentation Disorders / chemically induced*,  pathology
Pigments, Biological / analysis*
Tetracyclines / adverse effects*
Thyroid Diseases / chemically induced*,  pathology
Thyroid Gland / analysis,  pathology
Reg. No./Substance:
0/Lipofuscin; 0/Pigments, Biological; 0/Tetracyclines; 10118-90-8/Minocycline

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