Document Detail

Thyroid functions in lithium-treated psychiatric patients: a cross-sectional study.
MedLine Citation:
PMID:  10073421     Owner:  NLM     Status:  MEDLINE    
In the present cross-sectional study, thyroid functions (viz. thyroid radioiodine uptake [RAIU] and serum T3, T4, and thyroid-stimulating hormone [TSH]) were evaluated in 24 healthy controls and 132 outdoor affective disorder patients. Eleven of these patients were to receive lithium (Li) and the remaining 121 patients were at different stages of Li treatment ranging from 0.7 to 240 mo. RAIU was found to increase significantly throughout the Li therapy and was associated with the corresponding rise in TSH levels. In totality, Li treatment induced subclinical hypothyroidism in 51/132 (39%) of patients. However, 8/51 patients who belonged to known iodine-deficient belt had abnormally high TSH (range 15.2-76.0 microIU/mL), low T4 (5.3+/-2.5 microg/dL), and normal T3 and at least 4 of these 8 patients were clinically hypothyroid. T4 levels declined significantly (p < 0.05) with Li treatment ranging from 61 to 240 mo as compared to the corresponding values in the pre-Li group. The T3/T4 ratio was found to be significantly higher with Li treatment ranging from 0.7 to 6 mo in comparison with the pre-Li group and this value returned to base levels after long-term Li therapy. High T3 and T4 were observed in 13% and 12% of the patients, respectively, as compared to the corresponding control values.
S D Deodhar; B Singh; C M Pathak; P Sharan; P Kulhara
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  67     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-21     Completed Date:  1999-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-63     Citation Subset:  IM    
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Cross-Sectional Studies
Iodine Radioisotopes / metabolism
Lithium / adverse effects,  metabolism,  pharmacology*,  therapeutic use
Middle Aged
Mood Disorders / drug therapy*,  metabolism
Thyroid Gland / drug effects*,  metabolism*
Thyrotropin / blood
Thyroxine / blood
Time Factors
Triiodothyronine / blood
Reg. No./Substance:
0/Iodine Radioisotopes; 6893-02-3/Triiodothyronine; 7439-93-2/Lithium; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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