Document Detail

Thyroid function tests and thyroid autoantibodies in an unselected population of women undergoing first trimester screening for aneuploidy.
MedLine Citation:
PMID:  19032663     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Thyroid dysfunction in early pregnancy is associated with a number of adverse outcomes. Furthermore, the presence of thyroid autoantibodies has been associated with an increased risk of miscarriage. OBJECTIVE: To determine the prevalence of thyroid autoantibodies and their effect on thyroid function tests in an unselected population of women in early pregnancy. DESIGN AND SETTING: Cross-sectional study of samples that were collected for aneuploidy screening between 10 and 14 weeks gestation in Northern Sydney Area Health Service. Thyroid function tests (free T3, free T4 and thyroid-stimulating hormone) and thyroid autoantibodies to thyroperoxidase and thyroglobulin were measured. PATIENTS AND METHODS: Thyroid function tests were performed on a random sample of 257 blood samples. RESULTS: The presence of thyroid autoantibodies was common (18.3%) and was associated with subtle changes in thyroid function consistent with impaired thyroidal reserve. CONCLUSIONS: The prevalence of antithyroid Abs in an unselected pregnant population in the late first trimester was about 18%.
Aidan McElduff; Jonathan Morris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  48     ISSN:  1479-828X     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-04-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  478-80     Citation Subset:  IM    
Department of Endocrinology, Royal North Shore Hospital, and Department of Obstetrics and Gynaecology, University of Sydney, St Leonards, Sydney, New South Wales, Australia.
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MeSH Terms
Autoantibodies / blood*
Cross-Sectional Studies
Pregnancy Complications / diagnosis
Pregnancy Trimester, First / blood,  immunology
Thyroid Diseases / blood,  diagnosis*,  immunology
Thyroid Function Tests*
Thyroid Gland / immunology*,  physiology*
Thyrotropin / blood,  immunology
Thyroxine / blood,  immunology
Triiodothyronine / blood,  immunology
Reg. No./Substance:
0/Autoantibodies; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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