| Thyroid function and lipid profile in bipolar I patients. | |
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MedLine Citation:
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PMID: 23051081 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: This study aims to evaluate the prevalence of thyroid dysfunctions and to explore their association with perturbations in lipid profile in bipolar I patients. PATIENTS AND METHODS: Our study included 130 bipolar I patients diagnosed according to the DSM IV, and 124 control subjects aged respectively 37.9±12.1 and 37.6±13.2 years. TSH and FT4 were determined using electrochemiluminescence. Total cholesterol, triglycerides, c-LDL and c-HDL were determined by enzymatic colorimetric methods and ApoA1, ApoB and Lp(a) by immunoturbidimetric techniques on Konélab 30™. RESULTS: Patients had significantly higher TSH values than controls and had perturbations in lipid profile. 0.7% and 28.5% of patients had respectively hyperthyroidism and hypothyroidism. Hypothyroidism was associated with obesity and perturbations in lipid profile particularly increase in total cholesterol, c-LDL, ApoB, ApoB/ApoA1 and Lp(a) and decrease in ApoA1 and c-HDL. Moreover, it was associated with lithium and valproic acid treatment. CONCLUSIONS: Hypothyroidism was frequent in bipolar patients. It was significantly associated with obesity and perturbations in lipid profile. Therefore, bipolar patients require specific care, particularly for thyroid, lipid profile and weight; the effectiveness of this care will be evaluated during follow-up period. |
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Authors:
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Asma Ezzaher; Dhouha Haj Mouhamed; Anwar Mechri; Fadoua Neffati; Wahiba Douki; Lotfi Gaha; Mohamed Fadhel Najjar |
Publication Detail:
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Type: Journal Article Date: 2011-06-10 |
Journal Detail:
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Title: Asian journal of psychiatry Volume: 4 ISSN: 1876-2026 ISO Abbreviation: Asian J Psychiatr Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2012-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517820 Medline TA: Asian J Psychiatr Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-43 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratory of Biochemistry-Toxicology, Monastir University Hospital, Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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