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Thyroid function and lipid profile in bipolar I patients.
MedLine Citation:
PMID:  23051081     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: This study aims to evaluate the prevalence of thyroid dysfunctions and to explore their association with perturbations in lipid profile in bipolar I patients.
PATIENTS AND METHODS: Our study included 130 bipolar I patients diagnosed according to the DSM IV, and 124 control subjects aged respectively 37.9±12.1 and 37.6±13.2 years. TSH and FT4 were determined using electrochemiluminescence. Total cholesterol, triglycerides, c-LDL and c-HDL were determined by enzymatic colorimetric methods and ApoA1, ApoB and Lp(a) by immunoturbidimetric techniques on Konélab 30™.
RESULTS: Patients had significantly higher TSH values than controls and had perturbations in lipid profile. 0.7% and 28.5% of patients had respectively hyperthyroidism and hypothyroidism. Hypothyroidism was associated with obesity and perturbations in lipid profile particularly increase in total cholesterol, c-LDL, ApoB, ApoB/ApoA1 and Lp(a) and decrease in ApoA1 and c-HDL. Moreover, it was associated with lithium and valproic acid treatment.
CONCLUSIONS: Hypothyroidism was frequent in bipolar patients. It was significantly associated with obesity and perturbations in lipid profile. Therefore, bipolar patients require specific care, particularly for thyroid, lipid profile and weight; the effectiveness of this care will be evaluated during follow-up period.
Authors:
Asma Ezzaher; Dhouha Haj Mouhamed; Anwar Mechri; Fadoua Neffati; Wahiba Douki; Lotfi Gaha; Mohamed Fadhel Najjar
Publication Detail:
Type:  Journal Article     Date:  2011-06-10
Journal Detail:
Title:  Asian journal of psychiatry     Volume:  4     ISSN:  1876-2026     ISO Abbreviation:  Asian J Psychiatr     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517820     Medline TA:  Asian J Psychiatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Laboratory of Biochemistry-Toxicology, Monastir University Hospital, Tunisia.
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