| Thyroid function and its clinical significance in POEMS syndrome. | |
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MedLine Citation:
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PMID: 19863172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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POEMS syndrome, also known as Crow-Fukase syndrome, represents a rare multisystem syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Hypothyroidism is one of the common endocrine abnormalities which are central features of POEMS syndrome. The clinical data associated with the measurement of thyroid function and its clinical significance in POEMS syndrome is still rare. Herein, we report 24 cases with POEMS syndrome which were studied thyroid function and clinical manifestations and performed an associated analysis between hypothyroidism and edema/effusions. Of the 24 patients with POEMS syndrome, 17(70.8%) had a recognized hypothyroidism (including 11 clinical hypothyroidism and 6 subclinical hypothyroidism). Fourteen patients (58.3%) had some form of extravascular volume overload. In 14 patients with edema/effusions, 12 were diagnosed as having hypothyroidism. Hypothyroidism may be one of causes of edema/effusions. After thyroid hormone treatment and chemotherapy, symptoms of hypothyroidism and edema /effusions were improved greatly. |
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Authors:
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Xiao-Yi Dun; Fan Zhou; Hao Xi; Zhen-Gang Yuan; Jian Hou |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 50 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 2013-6 Citation Subset: IM |
Affiliation:
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Department of Hematology, Chang Zheng Hospital, The Second Affiliated Hospital of The Second Military Medical University, Shanghai 200003, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Enzyme-Linked Immunosorbent Assay Female Humans Hypothyroidism / complications, drug therapy* Male Middle Aged POEMS Syndrome / complications, drug therapy* Thyroid Function Tests Thyroxine / administration & dosage, therapeutic use* Treatment Outcome Vascular Endothelial Growth Factor A / blood |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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