Document Detail

Thyroid function in very-low-birth-weight infants with intraventricular hemorrhage.
MedLine Citation:
PMID:  11110365     Owner:  NLM     Status:  MEDLINE    
The objective of this investigation was to study the natural course of thyroid function in infants with intraventricular hemorrhage (IVH). A cohort of infants < 1,500 grams birth weight, n=247, were included in the analysis. Total T4 and thyrotropin from newborn screening during the 1st week of life (Test 1) and from repeat screening at 2-4 weeks postnatal age (Test 2) were compared in infants with IVH (n=43) and a group of infants without IVH. Fifty-nine percent of infants still had transient hypothyroxinemia at the time of Test 2. After multivariate analysis, infants with IVH had an increased odds of having a T4 < or = 6 microg/dL on Test 1 (OR 2.8, 95% CI 1.2-6.5), but at the time of Test 2 IVH was not associated with an increased odds of having a low T4. Only gestational age (OR 1.6, 95% CI 1.1-2.5) remained associated with an increased odds of having an extremely low T4 (< or = 4 microg/dL) at this time. Transient hypothyroxinemia remains common at 2-4 weeks of age in preterm infants. IVH is not independently associated with having a low T4 at this time.
D A Paul; K H Leef; J L Stefano; L Bartoshesky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical pediatrics     Volume:  39     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-6     Citation Subset:  AIM; IM    
Department of Pediatrics, Christiana Care Health Services, Newark, DE, USA.
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MeSH Terms
Biological Markers / blood
Cerebral Hemorrhage / blood,  etiology*
Cerebral Ventricles
Cohort Studies
Follow-Up Studies
Gestational Age
Hypothyroidism / blood*,  complications,  diagnosis
Infant, Newborn
Infant, Premature / metabolism*
Infant, Very Low Birth Weight / metabolism*
Mass Screening
Odds Ratio
Retrospective Studies
Thyroid Function Tests
Thyrotropin / blood*
Thyroxine / blood*
Reg. No./Substance:
0/Biological Markers; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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