Document Detail

Thyroid function in preterm infants 27-29 weeks of gestational age during the first four months of life: results from a prospective study comprising 80 preterm infants.
MedLine Citation:
PMID:  18341087     Owner:  NLM     Status:  MEDLINE    
AIM: Assessment of thyroid function in preterm neonates (PTN) 27-29 weeks of gestational age. PATIENTS AND METHODS: 80 PTN, gestational age 27 weeks in 24, 28 weeks in 28, and 29 weeks in 28. Neonates were classified as healthy (n=17) or sick (n=63). Measurement of serum TSH, free T4, T4, T3 and rT3 in the mother and in the cord at the time of delivery, and in the infant at 1 hour, 24 hours, 1 week, 3 weeks, and 2 and 4 months of postnatal age. RESULTS: In healthy and sick preterms, TSH values peaked at 1 hour and decreased thereafter. Healthy PTN presented a peak in free T4 values at 24 hours that was not observed in sick neonates. Sick PTN had a lower TSH peak and lower free T4 values at 24 hours and 1 week than healthy ones (p < 0.05). Healthy PTN 27-29 weeks had lower TSH peak at 1 hour and lower free T4, T3 and T4 values during the first 2 months than healthy PTN 30-35 weeks (PTN30-35w) previously evaluated (p < 0.05). However, at all postnatal times healthy preterms had free T4 values above -2 SD of the mean values of healthy PTN30-35w. A wide range of free T4 values was observed in the sick group. Free T4 values above -2 SD of the mean values of healthy PTN30-35w were detected in a high proportion of sick PTN (58.3% at 24 hours, 73.5% at 1 week, 93.9% at 3 weeks, 85.1% at 2 months and 100% at 4 months). CONCLUSIONS: Prematurity and disease influence thyroid function, and consequently thyroid function should be individually assessed in preterms 27-29 weeks of gestation during the first 2 months of life.
María Clemente; Pilar Ruiz-Cuevas; Antonio Carrascosa; Neus Potau; Jordi Almar; Salvador Salcedo; Diego Yeste
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  20     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1269-80     Citation Subset:  IM    
Pediatric Endocrine Service, Children's Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain.
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MeSH Terms
Birth Weight / physiology
Databases, Factual / statistics & numerical data
Gestational Age
Infant, Newborn / blood
Infant, Newborn, Diseases / blood,  diagnosis,  epidemiology
Infant, Premature / blood*,  physiology*
Longitudinal Studies
Neonatal Screening / methods
Prospective Studies
Spain / epidemiology
Thyroid Function Tests
Thyroid Gland / physiology*
Thyrotropin / blood
Thyroxine / blood
Time Factors
Triiodothyronine / blood
Triiodothyronine, Reverse / blood
Reg. No./Substance:
5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin
Comment In:
J Pediatr Endocrinol Metab. 2007 Dec;20(12):1267-8   [PMID:  18341086 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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