Document Detail


Thyroid function in pregnancy.
MedLine Citation:
PMID:  21186204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in understanding the physiology of thyroid function in normal pregnancy have highlighted the importance of the consequences of abnormal function on obstetric outcome and foetal well-being. Pubmed search was done using the terms thyroid and pregnancy. Areas of agreement are the following: gestational normative reference ranges for thyroid function tests are required for proper interpretation of any abnormalities. Measurement of thyroid-stimulating antibodies and antithyroid peroxidase antibodies is useful for diagnosis of thyroid disease in pregnancy. Treatment of Graves' hyperthyroidism should be done with propylthiouracil for first trimester only, then carbimazole or methimazole. Patients on levothyroxine require an increase in dosage during gestation. Areas of controversy are the following: total thyroxine (TT4) versus Free T4 (FT4) assays in pregnancy. Screening for thyroid function in early gestation: should it be routinely performed on everyone? What tests are appropriate? Growing points are the following: physiology of thyroxine delivery to the foetus. Establishment of gestational thyroid hormone reference ranges. Evaluation of strategies to screen thyroid function in early pregnancy. Areas timely for developing research are the following: placental thyroid hormone physiology, thyroid hormone therapy and screening thyroid function.
Authors:
John H Lazarus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-23
Journal Detail:
Title:  British medical bulletin     Volume:  97     ISSN:  1471-8391     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-05-27     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-48     Citation Subset:  IM    
Affiliation:
Centre for Endocrine and Diabetes Sciences, Cardiff University School of Medicine, University Hospital of Wales, Heath Park, UK. lazarus@cf.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Pregnancy / physiology
Pregnancy Complications / diagnosis*,  physiopathology
Reference Values
Thyroid Diseases / diagnosis*,  physiopathology
Thyroid Function Tests / methods
Thyroid Gland / physiology,  physiopathology*
Grant Support
ID/Acronym/Agency:
065143/A/01/2//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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