Document Detail


Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development.
MedLine Citation:
PMID:  19258403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: The effect of constant rich iodine intake, especially during pregnancy, has not been well understood. OBJECTIVE: The objective was to examine urinary iodine excretion and thyroid function in early pregnancy in Japanese healthy women. We also studied fetal maturation and child development in these women. DESIGN AND SETTING: This study was an observational, prospective study conducted at a maternity hospital. SUBJECTS: Subjects were 622 pregnant women who visited a maternity hospital consecutively in early gestation. Subjects with positive thyroid antibodies were excluded, and finally 514 subjects were examined. Offspring subjects were infants born to the maternal subjects. MAIN OUTCOME MEASURES: Thyroid function, serum thyroperoxidase antibodies, and urinary concentrations of iodine were measured at the initial obstetrical visit. The fetal maturation scores estimated by the Dubowitz and Ballard methods in newly born infants were assessed. A child developmental test was performed using the Enjoji Scale up to 12 months of age. RESULTS: The distribution of urinary iodine concentrations was large, and the average was extremely high. There were significant positive correlations between urinary iodine and serum TSH (r = 0.1326; P < 0.005). Serum TSH during early pregnancy in mothers had no relevance to parameters in neonates, scores of fetal maturation, or child developmental testing in their infants. CONCLUSIONS: Iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese women. To avoid hypothyroidism, reducing excess dietary iodine intake to moderate intake may be beneficial for pregnant woman in Japan.
Authors:
Yoshiko Orito; Hisato Oku; Sumihisa Kubota; Nobuyuki Amino; Kayoko Shimogaki; Mitsutaka Hata; Kazumi Manki; Yukiko Tanaka; Shoko Sugino; Michio Ueta; Kaori Kawakita; Takaaki Nunotani; Nobuya Tatsumi; Kiyoshi Ichihara; Akira Miyauchi; Megumi Miyake
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Publication Detail:
Type:  Journal Article     Date:  2009-03-03
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  94     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1683-8     Citation Subset:  AIM; IM    
Affiliation:
Palmore Hospital, Kobe 470, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Child Development*
Diet
Female
Fetal Blood / chemistry
Fetal Development*
Humans
Infant
Infant, Newborn
Iodide Peroxidase / blood
Iodine / urine*
Japan / epidemiology
Pregnancy / physiology*
Pregnancy Complications / epidemiology*
Prospective Studies
Thyroid Function Tests*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Vomiting / epidemiology*
Chemical
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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