| Thyroid function in Fabry disease before and after enzyme replacement therapy. | |
| | |
MedLine Citation:
|
PMID: 21460782 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
METHODS: Study population included 14 FD patients (7 females, 7 males, aged 21-62 years) and 14 sex- and age-matched normal subjects. Thyroid function was evaluated in each patient at baseline and after the beginning of ERT with rh-a-galactosidase-A (1 mg/kg/BW every 2 weeks) for three years. RESULTS: TSH levels were higher in FD patients than in controls (P<0.05). In FD patients, TSH levels were higher before than after ERT (1.9±0.2 vs 1.2±0.2 mU/L, P<0.01) while fT3 and fT4 levels were normal at baseline and unchanged after ERT. At baseline, TSH levels were >3 mU/L in three patients and normalize after ERT. Anti-Tg and/or anti-TPO titres were positive in 14% of patients and 21% of controls. After ERT, the rate of autoimmunity was unchanged. At the thyroid ultrasonography, a slight hypoechoic pattern was found in 71% of patients at baseline and decreased to 43% after ERT. CONCLUSION: Primary hypothyroidism in FD patients is reverted after long-term ERT. A screening of thyroid function and periodical re-evaluation during ERT is mandatory in all FD patients. |
| | |
Authors:
|
A Faggiano; R Severino; V Ramundo; R Russo; L Vuolo; M Del Prete; F Marciello; G Lombardi; B Cianciaruso; A Colao; A Pisani |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Minerva endocrinologica Volume: 36 ISSN: 0391-1977 ISO Abbreviation: Minerva Endocrinol. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406505 Medline TA: Minerva Endocrinol Country: Italy |
Other Details:
|
Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
|
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy - afaggian@unina.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute dissection of the left anterior descending after contusio cordis.
Next Document: New guidelines for the management of thyroid nodules and differentiated thyroid cancer.