Document Detail

Thyroid function and dysfunction in premature infants.
MedLine Citation:
PMID:  17643079     Owner:  NLM     Status:  MEDLINE    
During the past four decades major advances in the management of premature infants have led to progressive reduction in mortality. During this period mortality in very low birth weight infants (VLBW, <1500 grams and <30 weeks gestation age) has decreased, and more than 50% of infants less than 24 weeks gestation age now survive, increasing the population of VLBW infants in intensive care nursery environments. Thyroid function in these infants is characterized by decreased TSH and T4 responses to parturition, low serum total T4 and TSH levels and variable free T4 concentrations during the first 2-4 postnatal weeks of life. These features reflect a state of transient hypothalamic-pituitary or central hypothyroidism. There is a high prevalence of morbidity in these infants, as well, often associated with further reductions in serum total T4, T3, TBG and TSH concentrations and variable levels of free T4 and reverse T3, resembling the non-thyroidal illness (NTI) syndrome in adults. The etiologic roles of thyroid system immaturity and NTI in the transient hypothyroxinemia of prematurity (THOP) and the impact of THOP on the subsequent neurological deficits in VLBW infants remains unclear. Several thyroxine supplementation trials have been conducted with inconclusive results. Further studies are planned or in progress.
Delbert A Fisher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  4     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-11     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  317-28     Citation Subset:  IM    
David Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509, USA.
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MeSH Terms
Child Development
Hypothalamo-Hypophyseal System / metabolism
Hypothyroidism / blood*
Infant, Newborn
Infant, Premature / blood*
Infant, Very Low Birth Weight / blood*
Thyroid Function Tests
Thyroid Gland / metabolism,  physiopathology*
Thyroid Hormones / blood*
Reg. No./Substance:
0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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