Document Detail

Thyroid follicular neoplasm: analysis by fine needle aspiration cytology, frozen section, and histopathology.
MedLine Citation:
PMID:  20014303     Owner:  NLM     Status:  MEDLINE    
We performed a retrospective analysis of follicular neoplasm data obtained from frozen section examinations of thyroid nodules. A total of 5,660 patients underwent preoperative neck ultrasonography and fine-needle aspiration cytology (FNAC), surgical treatment, and follow-up at a medical institute. Patients with papillary thyroid microcarcinoma were excluded from this study. In 971 cases, frozen section examination was performed during the surgical treatment of follicular neoplasm that was diagnosed via FNAC. Thyroid malignancies were histologically confirmed in 25.1% of cases (244/971). Among the patients with papillary thyroid carcinoma, 45 were diagnosed with the follicular variant of papillary thyroid carcinomas (27.4%). The diagnostic sensitivity of frozen section for the nonfollicular variant of papillary thyroid carcinoma was better than that for the follicular variant of papillary thyroid carcinoma (89.1% versus 78.9%; P = 0.1023). For 12 cases the diagnosis was atypical follicular adenomas. The diagnostic accuracy of frozen section in cases of follicular neoplasm was 76.9% with a sensitivity of 84.8% and a specificity of 98.9%. In conclusion, our analysis revealed high rates of accuracy when using frozen tissue sections for early diagnosis and treatment of follicular neoplasm; thus, an early decision to extent of surgery prevents a risky follow-up surgery.
Feng-Hsuan Liu; Miaw-Jene Liou; Chuen Hsueh; Tzu-Chieh Chao; Jen-Der Lin
Related Documents :
2862853 - Hyperthyroidism after primary hypothyroidism. follow-up with serial thyroid biopsies.
12114783 - Clear-cell follicular adenoma of ectopic thyroid in the submandibular region.
24693883 - Fetus in fetu: two case reports and literature review.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  38     ISSN:  1097-0339     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  801-5     Citation Subset:  IM    
Copyright Information:
© 2009 Wiley-Liss, Inc.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taiwan, Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma, Follicular / pathology*
Biopsy, Fine-Needle
Frozen Sections*
Retrospective Studies
Sensitivity and Specificity
Thyroid Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fluorescent high-content imaging allows the discrimination and quantitation of E-LDL-induced lipid d...
Next Document:  Can mobile units improve the strategies for cervical cancer prevention?