Document Detail

Thyroid failure and protirelin (thyrotropin-releasing hormone) test abnormalities in depressed outpatients.
MedLine Citation:
PMID:  6402617     Owner:  NLM     Status:  MEDLINE    
Forty-four consecutive outpatients referred to a psychiatric hospital for evaluation of depression and anergia were assessed by means of the protirelin (thyrotropin-releasing hormone) test. Nineteen patients (43%) had a blunted thyrotropin (TSH) response to protirelin, while six patients (13.5%) had augmented TSH responses indicating some degree of hypothyroidism. One patient had a low thyroxine level, while three patients had elevated basal TSH levels. Five of the six patients with augmented TSH responses were found to have antithyroid antibodies. These results suggest that a majority of depressed outpatients have abnormalities on the protirelin test and that the TSH response to protirelin is useful in both confirming a diagnosis of major depression and assessing thyroid status.
H A Sternbach; M S Gold; A C Pottash; I Extein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  249     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1618-20     Citation Subset:  AIM; IM    
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MeSH Terms
Cachexia / diagnosis,  epidemiology,  physiopathology
Depressive Disorder / diagnosis*,  physiopathology
Hypothyroidism / diagnosis*,  epidemiology,  physiopathology
Middle Aged
Thyroid Function Tests*
Thyroid Gland / physiopathology
Thyrotropin / blood*
Thyrotropin-Releasing Hormone / diagnostic use*,  pharmacology
Thyroxine / blood
Reg. No./Substance:
5Y5F15120W/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin; Q51BO43MG4/Thyroxine

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