Document Detail

Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome.
MedLine Citation:
PMID:  23412858     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyroid dysfunction is very common and is associated with neurodevelopmental impairments in preterm infants.
OBJECTIVES: This study was conducted to determine the incidence and natural course of various thyroid dysfunctions and their impacts on neurodevelopmental outcomes among premature infants.
METHODS: A total of 177 infants were enrolled who were born at <34 weeks or whose birth weight was <1500 g and who underwent repeat thyroid function tests. We analyzed how various thyroid dysfunctions affected neurodevelopmental outcomes at 18 months of corrected age.
RESULTS: Thyroid dysfunction was noted in 88 infants. Hypothyroxinemia was observed in 23 infants, and their thyroid function was influenced by variable clinical factors. Free T4 levels were all normalized without thyroxine medication, and neurodevelopmental outcomes were not affected. In contrast, hyperthyrotropinemia was not associated with other clinical factors. Among 58 subjects who had hyperthyrotropinemia, only 31 infants showed normal thyroid-stimulating hormone (TSH) levels at follow-up tests. The remaining 27 infants had persistently high TSH levels, which significantly and poorly influenced the neurodevelopmental outcomes.
CONCLUSIONS: Thyroid dysfunction is common among preterm infants. With the exception of persistent hyperthyrotropinemia, it generally does not affect neurodevelopmental outcomes. However, the beneficial effects of thyroid hormone therapy in patients with persistent hyperthyrotropinemia merits further study.
Mi Lim Chung; Han Wok Yoo; Ki-Soo Kim; Byong Sop Lee; Soo-Young Pi; Gina Lim; Ellen Ai-Rhan Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  26     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2013  
Date Detail:
Created Date:  2013-05-03     Completed Date:  2013-08-20     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  449-55     Citation Subset:  IM    
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MeSH Terms
Child Development / physiology*
Congenital Hypothyroidism / diagnosis,  physiopathology*
Infant, Newborn
Infant, Premature / growth & development*
Infant, Very Low Birth Weight / growth & development*
Multivariate Analysis
Nervous System / growth & development
Thyroid Function Tests
Thyroid Gland / growth & development*,  physiology
Thyrotropin / blood
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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