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Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism.
MedLine Citation:
PMID:  21872555     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass. The contaminant mixture was formulated to reflect the persistent organic pollution to which the European sea bass population could conceivably be exposed (0.3, 0.6 and 1.0μg Σ7PCBs per g food pellets) and higher (10μg Σ7PCBs per g food pellets). After 120 days of exposure, histomorphometry of thyroid tissue, muscular thyroid hormone concentration and activity of enzymes involved in metabolism of thyroid hormones were assessed. Mean concentrations of 8, 86, 142, 214 and 2279ngg(-1)ww (Σ7 ICES PCB congeners) were determined after 120 days exposure. The results show that the effects of PCB exposures on the thyroid system are dose-dependent. Exposure to environmentally relevant doses of PCB (0.3-1.0μg Σ7PCBs per g food pellets) induced a larger variability of the follicle diameter and stimulated hepatic T(4) outer ring deiodinase. Muscular thyroid hormone levels were preserved thanks to the PCB induced changes in T(4) dynamics. At 10 times higher concentrations (10μg Σ7PCBs per g food pellets) an important depression of T(3) and T(4) levels could be observed which are apparently caused by degenerative histological changes in the thyroid tissue.
Authors:
Joseph G Schnitzler; Niko Celis; Peter H M Klaren; Ronny Blust; Alin C Dirtu; Adrian Covaci; Krishna Das
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-4
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  105     ISSN:  1879-1514     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  438-447     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Mare Centre, Laboratory for Oceanology B6c, Liège University, Liège, Belgium.
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