| Thyroid dysfunction in infertile women. | |
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MedLine Citation:
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PMID: 17462173 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To determine the frequency of thyroid dysfunction in infertile women referred for thyroid evaluation. Design: A retrospective case-control study. Place and Duration of Study: This study was carried out at Centre for Nuclear Medicine (CENUM), Mayo Hospital, Lahore, from July 2003 to December 2006. Patients and Methods: Age matched infertile (n=140 each) and fertile women (n=152 each) referred to CENUM for thyroid evaluation were investigated for incidence of hyperthyroidism (TSH < 0.03 mIU/L), hypothyroidism (TSH < 0.03 mIU/L) and thyroid autoimmunity (antithyroid peroxidase antibody titer>20 IU/L). Serum free T4 (FT4), free T3 (FT3) and antithyroid peroxidase antibody (TPO-Ab) was determined by radioimmunoassay (RIA) and TSH by immunoradiometric assay (IRMA). Results: Most of the infertile women (89.3%), like control women (93.4%), were euthyroid. The difference of overall thyroid dysfunction was not statistically significant in infertile and control women (10.7% vs. 7.9%; p=0.395). The same was true for incidence of hyperthyroidism (4.3% vs. 5.3%; p=0.701) as well as hypothyroidism (6.4% vs. 2.6%; p=0.104). In infertile women, the incidence of hypothyroidism (6.4%) was slightly higher as compared to hyperthyroidism (4.3%). In euthyroid women of both groups, mean FT4, FT3 and TSH levels were significantly higher (p < 0.05) in infertile women and double number of them had serum TSH>2.5 mIU/L compared to fertile women (31.2% vs. 15.6%; p<0.01). Similarly, more infertile women were TPO-Ab positive (titer>20 IU/L) than control women (7.2% vs. 1.4%; p < 0.05). Conclusion: Increased incidence of high normal TSH and raised TPO-Ab titer indicate relatively more frequent occurrence of compensated thyroid function in infertile women than normal women of reproductive age. This necessitates considering them a subgroup of women in which all aspects of pituitary-thyroid axis should be thoroughly investigated than merely TSH testing. |
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Authors:
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Shan Elahi; Affia Tasneem; Irfana Nazir; Saeed Ahmed Nagra; Syed Waqar Hyder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 17 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
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Languages: eng Pagination: 191-4 Citation Subset: IM |
Affiliation:
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Centre for Nuclear Medicine (CENUM), Mayo Hospital, Lahore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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