Document Detail


Thyroid dysfunction in antiviral therapy of chronic hepatitis C.
MedLine Citation:
PMID:  21033237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Thyroid disorders are common dysfunctions during HCV infection and IFN-therapy. The aim of the study was to evaluate the general risk of thyroid disorders' development in chronic HCV-infected patients and their possible relationship with HCV genotype, type of used IFN-alpha and viral response.
METHODOLOGY: A study was performed in 89 patients with chronic hepatitis C (57 males, 32 females) and 25 healthy subjects. All HCV-infected patients were treated by IFN-alpha and RBV for a period depending on the HCV genotype. Hematological parameters, liver and thyroid function tests were analyzed. Serum Tpo-Ab and TG-Ab were detected by semiquantitative ELISA. In statistical analyses U Mann-Whitney and Spearman correlation tests were used. Ap value < 0.05 was considered significant.
RESULTS: Twelve (13.5%) CHC patients developed thyroid disorders during IFN-alpha therapy. Thyroid disorders were more often detected in females, in 3a-genotype-infection and in patients treated with natural leukocyte IFN-alpha. Seven (7.6%) Tpo-Ab and/or TG-Ab positive patients were noticed. Four of them (57.1%) developed hypothyroidism during IFN-alpha therapy.
CONCLUSION: This study demonstrated low effect of IFN-alpha therapy on thyroid disorders development and on TPO-Ab and TG-Ab serum level in chronic HCV-infected patients.
Authors:
Magdalena M Dabrowska; Anatol Panasiuk; Robert Flisiak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  57     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  826-31     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases and Hepatology, Medical University of Bialystok, 14 Zurawia Str, 15-540 Bialystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiviral Agents / adverse effects,  therapeutic use*
Autoantibodies / analysis*
Cross-Sectional Studies
Female
Hepatitis C, Chronic / drug therapy*,  immunology*
Humans
Hypothyroidism / chemically induced
Interferon-alpha / adverse effects,  therapeutic use*
Male
Middle Aged
Thyroid Function Tests
Thyroid Gland / immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Autoantibodies; 0/Interferon-alpha; 0/anti-thyroglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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