Document Detail

Thyroid disease in relation to pregnancy: a decade of change.
MedLine Citation:
PMID:  10971442     Owner:  NLM     Status:  MEDLINE    
Inspection of the references cited in this review indicates that much work has occurred in the area of thyroid and pregnancy during the last decade. Significant advances in our understanding of the immunology of pregnancy and the effect of thyroid disease on this process have taken place. The role of hCG in the physiology of pregnancy and its relevance to thyroid function has been an emerging theme. There is still no clear explanation for the association between thyroid antibodies and infertility or miscarriage. During the last decade a general concensus has developed in relation to the management of hyperthyroidism in pregnancy although there are still variations in antithyroid drug use at this time. The aetiological classification of congenital hyper- and hypothyroidism utilizing new technologies has opened up a new perspective on these disorders. Attention has been drawn to the importance of treating maternal hypothyroidism with adequate thyroid replacement therapy and to the possibility of impaired child neuropsychological development consequent on low maternal thyroid hormone concentration in early gestation in non iodine deficient areas. Significant advances have been made during the last decade in the description of the clinical features and in our understanding of the pathogenesis of postpartum thyroid disease. The importance of long-term follow up of selected patient groups has also been emphasized.
J H Lazarus; A Kokandi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical endocrinology     Volume:  53     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-78     Citation Subset:  IM    
Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Abortion, Spontaneous / etiology
Autoantibodies / immunology
Autoimmune Diseases / immunology,  physiopathology,  therapy
Chorionic Gonadotropin / metabolism
Developmental Disabilities / etiology
HLA Antigens / immunology
Histocompatibility Antigens Class I / immunology
Hyperthyroidism / drug therapy,  immunology
Hypothyroidism / complications,  embryology
Immunoglobulins, Thyroid-Stimulating / immunology
Pregnancy Complications / immunology*,  physiopathology,  therapy
Puerperal Disorders / immunology,  physiopathology,  therapy
Thyroid Diseases / immunology*,  physiopathology,  therapy
Thyroid Gland / immunology
Thyroxine / therapeutic use
Trophoblasts / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Chorionic Gonadotropin; 0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I; 0/Immunoglobulins, Thyroid-Stimulating; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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